Symptoms
Red flag symptoms

Symptoms

Symptoms

Red flag symptoms

Red flag symptoms

Awareness of the full spectrum of systemic manifestations of hATTR is important for early recognition of suspicious signs and symptoms1

Peripheralsensorimotorneuropathyone or moreof thesesymptomsmay indicatehATTR2–4GastrointestinalmanifestationsAutonomic neuropathyBilateral carpaltunnel syndromeNephropathyOcular manifestationsCardiovascularmanifestationsSpinal stenosis

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About hATTR

About hATTR

Hereditary transthyretin amyloidosis is a rapidly progressive and life-shortening disease

Disease mechanism

Disease mechanism

Mechanism of TTR amyloid formation

Diagnosis

Diagnosis

Clinical suspicion index varies between endemic and non-endemic areas5

Disease progression

Disease progression

hATTR is progressive and physical function deteriorates rapidly6

Living with hATTR

Living with hATTR

hATTR is difficult to live with3,7

About Tegsedi

About Tegsedi

For your hATTR patients with stage 1 or 2 polyneuropathy, what matters is now

References
  1. Gertz M, Adams D et al., BMC Fam Pract. 2020 Sep 23;21(1):198.
  2. Conceição I et al. “Red-flag” symptom clusters in transthyretin familial amyloid polyneuropathy. J Peripher Nerv Syst. 2016;21(1):5–9.
  3. Gertz MA. Hereditary ATTR amyloidosis: burden of illness and diagnostic challenges. Am J Manag Care. 2017;23(suppl 7):S107–S112.
  4. Donnelly JP & Hanna M. Cardiac amyloidosis: an update on diagnosis and treatment. Cleve Clin J Med. 2017;84(12 suppl 3):12–26.
  5. Adams D, Ando Y et al., J Neurol. 2021 Jun;268(6):2109-212.
  6. Monteiro C, Mesgazardeh JS et al. Predictive model of response to tafamidis in hereditary ATTR polyneuropathy. JCI Insight. 2019 Jun 20;4(12):e126526
  7. Amyloidosis Foundation. Understanding the patient voice in hereditary transthyretin-mediated amyloidosis (ATTR amyloidosis). Available at: https://www.amyloidosissupport.org/support_groups/fam_isabell_attr.pdf. Accessed April 2020.