Disease mechanism
Mechanism of TTR amyloid formation

Disease mechanism

Mechanism of TTR amyloid formation

Mechanism of TTR amyloid formation

TTR gene mutations cause transthyretin protein to deposit as amyloid in multiple organs and body systems causing progressive dysfunction and eventually death.1,2

About hATTR
Symptoms
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About hATTR

About hATTR

Hereditary transthyretin amyloidosis is a rapidly progressive and life-shortening disease

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Symptoms

Symptoms

Red flag symptoms

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Diagnosis

Diagnosis

Clinical suspicion index varies between endemic and non-endemic areas3

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Disease progression

Disease progression

hATTR is progressive and physical function deteriorates rapidly4

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Living with hATTR

Living with hATTR

hATTR is difficult to live with5,6

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About Tegsedi

About Tegsedi

For your hATTR patients with stage 1 or 2 polyneuropathy, what matters is now

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References
  1. Johnson SM, Connelly S, Fearns C, Powers ET, Kelly JW. The transthyretin amyloidosis: from delineating the molecular mechanism of aggregation linked to pathology to a regulatory agency approved drug. J Mol Biol. 2012;421(2-3):185-203.
  2. Ando Y et al. Guideline of transthyretin-related hereditary amyloidosis for clinicians. Orphanet J Rare Dis. 2013;8:31.
  3. Adams D, Ando Y et al., J Neurol. 2021 Jun;268(6):2109-212.
  4. Monteiro C, Mesgazardeh JS et al. Predictive model of response to tafamidis in hereditary ATTR polyneuropathy. JCI Insight. 2019 Jun 20;4(12):e126526
  5. Gertz MA. Hereditary ATTR amyloidosis: burden of illness and diagnostic challenges. Am J Manag Care. 2017;23(suppl 7):S107–S112.
  6. Amyloidosis Foundation. Understanding the patient voice in hereditary transthyretin-mediated amyloidosis (ATTR amyloidosis). Available at: https://www.amyloidosissupport.org/support_groups/fam_isabell_attr.pdf. Accessed April 2020.