Disease progression
hATTR is progressive and physical function deteriorates rapidly(1)

Disease progression

Disease progression

hATTR is progressive and physical function deteriorates rapidly(1)

hATTR is progressive and physical function deteriorates rapidly1


Patients’ ability to perform everyday tasks significantly declines as hATTR progresses4


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About hATTR

About hATTR

Hereditary transthyretin amyloidosis is a rapidly progressive and life-shortening disease

Disease mechanism

Disease mechanism

Mechanism of TTR amyloid formation

Symptoms

Symptoms

Red flag symptoms

Diagnosis

Diagnosis

Clinical suspicion index varies between endemic and non-endemic areas5

Living with hATTR

Living with hATTR

hATTR is difficult to live with6,7

About Tegsedi

About Tegsedi

For your hATTR patients with stage 1 or 2 polyneuropathy, what matters is now

References
  1. Monteiro C, Mesgazardeh JS et al. Predictive model of response to tafamidis in hereditary ATTR polyneuropathy. JCI Insight. 2019 Jun 20;4(12):e126526
  2. Adams D. Ther Adv Neurol Disord. 2013;6(2):129–139.
  3. Coutinho P et al, Forty years of experience with type I amyloid neuropathy. Review of 483 cases. In: Glenner G, Costa P, de Freitas A (Editors), Amyloid and amyloidosis. Amsterdam: Excerpta Medica; 1980. p. 88–98. * Due to early onset (<50 years) Val30met
  4. Berk J et al. Impact of Hereditary Transthyretin-Mediated Amyloidosis on Daily Living and Work Productivity: Baseline Results from APOLLO. Presented at the 16th International Symposium on Amyloidosis (ISA), March 26–29, 2018, Kumamoto, Japan.
  5. Adams D, Ando Y et al., J Neurol. 2021 Jun;268(6):2109-212.
  6. Gertz MA. Hereditary ATTR amyloidosis: burden of illness and diagnostic challenges. Am J Manag Care. 2017;23(suppl 7):S107–S112.
  7. Amyloidosis Foundation. Understanding the patient voice in hereditary transthyretin-mediated amyloidosis (ATTR amyloidosis). Available at: https://www.amyloidosissupport.org/support_groups/fam_isabell_attr.pdf. Accessed April 2020.